As Week 6 of the 2025 college football season approaches, fans can expect an exciting slate of games that could significantly impact the national landscape. While this week may not feature many ranked-on-ranked matchups, six teams from the AP Top 25 will travel to face unranked opponents, setting the stage for potential upsets and thrilling action.
The day kicks off with the No. 14 Iowa State Cyclones facing off against a resurgent Cincinnati team. This matchup showcases two of the Big 12's most captivating quarterbacks, Rocco Becht from Iowa State and Brendan Sorsby from Cincinnati. With both teams eager to make their mark, this game promises to be a compelling start to Saturday's action.
The mid-afternoon schedule is packed with intriguing contests. No. 7 Penn State and No. 9 Texas will embark on challenging road trips, taking on UCLA and Florida, respectively. Meanwhile, in Tuscaloosa, No. 10 Alabama will host No. 16 Vanderbilt in one of the few ranked-versus-ranked matchups of the day. Additionally, No. 21 Notre Dame is set to welcome Boise State in a rematch of teams that participated in the 2024 College Football Playoff.
As night falls, the spotlight shifts to the ACC with a highly anticipated rivalry game. No. 3 Miami will visit No. 18 Florida State in a matchup that not only carries historical significance but also serves as an early indicator of league supremacy. Both teams are looking to assert their dominance in the conference, making this a must-watch showdown.
Don’t overlook the Houston Cougars, who remain one of the two undefeated FBS teams yet to receive an AP Top 25 vote. They will host No. 11 Texas Tech in a game that has all the makings of an upset, adding an extra layer of intrigue to the weekend's lineup.
Kickoff: Noon on CBS, CBSSports.com, CBS Sports App, Paramount+ Premium
The matchup between the service academies has historically favored the under, but recent trends have challenged that notion. Both teams utilize a triple-option attack, yet with Air Force's weak defense, the total points for this game could be at risk. With Navy averaging 31.5 seconds per play and Air Force at 27.6, expect a slow-paced game. The expert pick is Under 49.5.
Kickoff: Noon on ESPN, fuboTV (try for free)
Both teams have struggled offensively this season, making it hard to predict a high-scoring affair. North Carolina's defense is stronger, and Clemson's defense could capitalize on any mistakes. This contest is expected to be a defensive battle, with the expert pick being Under 46.5.
Kickoff: Noon on Fox, fuboTV (try for free)
Despite previous hopes for an upset, the expert believes No. 20 Michigan has the advantage with superior talent. Freshman QB Bryce Underwood is gaining confidence, making it tough for Wisconsin to compete. The pick is Michigan -17.5.
Kickoff: 3:30 p.m. on NBC, fuboTV (try for free)
With Notre Dame's offense scoring over 40 points in their last three games, the expectation for this contest is high. Boise State's offense has also shown promise, leading to an anticipated high-scoring game. Experts suggest taking the Over 64.5.
Kickoff: 3:30 p.m. on CBS, CBSSports.com, CBS Sports App, Paramount+ Premium
After a tough loss, Penn State aims to bounce back against UCLA, who is still seeking their first lead of the season. Despite Penn State's defensive strength, UCLA is expected to cover the spread, making the pick UCLA +26.5.
Kickoff: 3:30 p.m. on ESPN, fuboTV (try for free)
Texas faces concerns about their offense, but their defense is poised to control Florida's passing game. Analysts predict a dominant performance from the Longhorns, with the pick being Texas -7.
Kickoff: 3:30 p.m. on ABC, fuboTV (try for free)
Alabama appears to be regaining form, led by elite quarterback Simpson. While Vanderbilt is expected to keep it competitive, the expert pick favors Alabama to win but with Vanderbilt covering the spread, making the pick Vanderbilt +10.5.
Kickoff: 7:30 p.m. on ABC, fuboTV (try for free)
Miami heads into this rivalry game with confidence, while Florida State looks to recover from recent missteps. The expert pick for this highly anticipated matchup is Miami -4.5.
As this thrilling week in college football unfolds, keep an eye on these crucial matchups that could alter the course of the season!
