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Week 4 NFL Predictions: Who Will Triumph in Key Matchups?

9/26/2025
As the NFL regular season reaches its first month, our experts predict outcomes for all Week 4 games. Will the surprising Colts continue their momentum? Get insights and betting odds!
Week 4 NFL Predictions: Who Will Triumph in Key Matchups?
Dive into our Week 4 NFL predictions and discover which teams are poised for victory and who might face shocking defeats. Don't miss out!

NFL Week 4 Preview: Predictions and Matchups

As we approach the end of the first month of the NFL regular season, it’s hard to believe how quickly time has flown. Just yesterday, it seemed like the Detroit Lions had closed their window of opportunity, the Green Bay Packers were an unstoppable force, and the Kansas City Chiefs appeared to be out of the race before it even began. A month from now, we’ll see if Daniel Jones and the Indianapolis Colts continue to be one of the most surprising stories in professional football. In the meantime, let’s check in on the New Orleans Saints—and don’t forget to reach out to any Saints fans you know, as they might need some support this season.

Weekly Predictions from Pride of Detroit Staff

As we’ve done in previous seasons, our dedicated staff at Pride of Detroit will be making weekly predictions for every game on the NFL schedule. Each member will provide their insights on the moneyline—picking the outright winner of the game without considering the spread. Some team members will also venture into picking against the spread and even forecast the over/under lines. You can easily toggle between these settings using the widget below. Be sure to check back each week to see our records and how we fare in our predictions.

Exciting Matchups This Week

This week, Thursday night will feature a thrilling matchup between division rivals at 8:15 p.m. ET on Amazon Prime. The Seattle Seahawks will travel to the desert to face off against the Arizona Cardinals. Both teams are currently sitting at 2-1, making this an exciting clash in the NFC West.

On Sunday, NFL fans can look forward to 13 games on the slate, including the return of the International Series. Tune in to NFL Network at 9:30 a.m. ET to catch the Pittsburgh Steelers as they go head-to-head with the Minnesota Vikings at Croke Park in Dublin, Ireland. This matchup is especially notable for fans who enjoyed last year’s game where the Vikings took down Aaron Rodgers across the pond.

For local Detroit fans, there are a couple of intriguing options in the early slot at 1 p.m. ET. On CBS, the Washington Commanders will take on the Atlanta Falcons at the Mercedes-Benz Stadium in Georgia. Simultaneously, on FOX, the hometown Detroit Lions will clash with the Cleveland Browns at Ford Field, promising an exciting game for the local audience.

Late Window and Sunday Night Football

The late afternoon window features a marquee matchup on CBS, where the Kansas City Chiefs will host the Baltimore Ravens at Arrowhead Stadium at 4:25 p.m. ET. Both teams are looking to avoid falling to 1-3 to start the season, making this a critical game for their playoff aspirations.

“Sunday Night Football” will cap off a full day of action with a compelling matchup as the Green Bay Packers visit the Dallas Cowboys at 8:20 p.m. ET on NBC. This game will be a significant test for both teams as they look to solidify their standings in the league.

Monday Night Football: Doubleheader Excitement

ESPN returns to its tradition of doubleheader Monday Night Football, kicking off at 7:15 p.m. ET with the New York Jets facing the Miami Dolphins. Both teams will be eager to shake off their winless records and secure a crucial victory. Following that, at 8:15 p.m. ET, the Cincinnati Bengals will travel to Colorado to take on the Denver Broncos on ABC, promising another thrilling matchup.

Stay Tuned for Predictions

Be sure to check back for our staff's picks on the moneyline, spread, and over/under for all 16 games on the NFL Week 4 schedule. With so many exciting matchups ahead, this week promises to be filled with action and unexpected outcomes!

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