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NFL Week 2: Must-See Matchups and Expert Betting Picks

9/12/2025
Get ready for an action-packed NFL Week 2! Our experts weigh in on the biggest matchups, betting odds, and who to trust with your bets. Find out which teams are poised for upsets and which stars will shine!
NFL Week 2: Must-See Matchups and Expert Betting Picks
Dive into NFL Week 2 with expert betting picks and analysis. Discover matchups, odds, and predictions that could change your game day experience!

Exciting NFL Matchups for Week 2: Predictions and Betting Insights

As we dive into another thrilling week of NFL action, fans are eagerly anticipating a series of must-see matchups. Following an eventful Week 1, which saw Daniel Jones excel against the Miami Dolphins and Justin Herbert lead his team to a dramatic victory over the Kansas City Chiefs, Week 2 promises to deliver more exciting games. In this article, we've compiled the best betting picks and insights from CBS Sports and SportsLine, ensuring you have all the information you need to make informed wagers.

Betting on NFL Week 2 Games

Ready to place your bets on NFL Week 2 games? You can find the latest NFL odds at DraftKings, where new users can take advantage of $200 in bonus bets and discounts on NFL Sunday Ticket. Click here to get started: All NFL odds via SportsLine consensus odds.

Key Matchups and Predictions

Jaguars vs. Bengals

Kickoff: Sunday, 1 p.m. ET on CBS | Stream on Paramount+

Bengals -3.5: The Cincinnati Bengals are looking to bounce back after a rocky start. Quarterback Joe Burrow threw for just 113 yards in Week 1, but history suggests he rarely underperforms in consecutive games. In fact, following games where he passes for under 200 yards, Burrow averages 298.4 passing yards and over two touchdowns. With the Jaguars defense having surrendered the most passing yards last season, expect a competitive matchup. CBS Sports writer John Breech predicts the Bengals will win 27-20.

Giants vs. Cowboys

Kickoff: Sunday, 1 p.m. ET on Fox | Stream: Fubo (Try for Free)

Giants +6: The Giants are grappling with quarterback issues, and many believe it's time to shift to rookie Jaxson Dart. Eric Cohen, a SportsLine expert, predicts a close game with the Cowboys potentially winning 27-23, but advises caution when betting on a six-point spread.

Bears vs. Lions

Kickoff: Sunday, 1 p.m. ET on Fox | Stream: Fubo (Try for Free)

The SportsLine simulation model has identified five strong betting options for Week 2. One highlight is the Lions (-5.5), who cover against the Bears over 60% of the time. Despite a shaky start against the Packers, the Lions are expected to recover and perform well.

Rams vs. Titans

Kickoff: Sunday, 1 p.m. ET on CBS | Stream: Paramount+

Titans +5.5: The Tennessee Titans impressed defensively last week, which could challenge a Rams offense that struggled despite their victory. Pete Prisco predicts a close win for the Rams but expects the Titans to cover the spread.

Patriots vs. Dolphins

Kickoff: Sunday, 1 p.m. ET on CBS | Stream: Paramount+

Patriots +1.5: This matchup revolves around the Dolphins' struggling offense and the questionable performance of their secondary. Tyler Sullivan believes this sets up a favorable scenario for the Patriots, who he predicts will secure a 24-20 victory.

49ers vs. Saints

Kickoff: Sunday, 1 p.m. ET on Fox | Stream: Fubo (Try for Free)

Saints +4.5: The SportsLine model is wary of the 49ers, especially after injuries to quarterback Brock Purdy and tight end George Kittle. The model suggests that the Saints could outperform expectations in 41% of simulations.

Bills vs. Jets

Kickoff: Sunday, 1 p.m. ET on CBS | Stream: Paramount+

Bills -6.5: The SportsLine model indicates that the Bills could be a strong bet, potentially returning more than $6,000 for a $10 bettor on top-rated picks. They are included in a 5-leg parlay that might yield lucrative returns.

Seahawks vs. Steelers

Kickoff: Sunday, 1 p.m. ET on Fox | Stream: Fubo (Try for Free)

Steelers -3: In their home opener, the Steelers are favored to defeat the Seahawks. Pete Prisco believes that quarterback Aaron Rodgers will continue to shine, leading the Steelers to a predicted 26-19 win.

Browns vs. Ravens

Kickoff: Sunday, 1 p.m. ET on CBS | Stream: Paramount+

With the Ravens coming off a tough loss, they are significant favorites against the Browns. R.J. White notes that survivor pool participants might heavily lean towards choosing the Ravens, given their favorable odds.

Broncos vs. Colts

Kickoff: Sunday, 4:05 p.m. ET on CBS | Stream: Paramount+

Colts +2.5: After a surprising performance from Daniel Jones in Indianapolis, John Breech favors the Colts, highlighting their strong showing in scoring during Week 1.

Panthers vs. Cardinals

Kickoff: Sunday, 4:05 p.m. ET on CBS | Stream: Paramount+

Cardinals -6.5: The SportsLine model shows a favorable trend for the Cardinals against the Panthers, predicting a strong possibility of covering the spread.

Eagles vs. Chiefs

Kickoff: Sunday, 4:25 p.m. ET on Fox | Stream: Fubo (Try for Free)

Eagles -1.5: Despite concerns about the Chiefs’ firepower, Tyler Sullivan believes the Eagles are primed for a victory in this Super Bowl LIX rematch, expecting their defense to shine.

Falcons vs. Vikings

Kickoff: Sunday, 8:20 p.m. on NBC | Stream: Fubo (Try for Free)

Before betting on J.J. McCarthy’s performance, consider expert advice from R.J. White, who has a strong track record with the Vikings.

Buccaneers vs. Texans

Kickoff: Monday, 7 p.m. ET on ABC/ESPN | Stream: Fubo (Try for Free)

In a matchup featuring the Buccaneers and Texans, both teams are looking to gain momentum. Micah Roberts has insights that you won't want to miss, given his impressive betting history.

Chargers vs. Raiders

Kickoff: Monday, 10 p.m. ET on ESPN | Stream: Fubo (Try for Free)

As we wrap up Week 2, keep an eye on the Chargers and Raiders as they face off in a highly anticipated matchup. Betting insights will be crucial for making informed decisions as the action unfolds.

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