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Are the Indianapolis Colts the Real Deal? Week 3 NFL Predictions Inside!

9/16/2025
With a 2-0 start, the Colts are eyeing dominance in the AFC South. Can Jonathan Taylor maintain his hot streak? Discover expert predictions for Week 3 and more!
Are the Indianapolis Colts the Real Deal? Week 3 NFL Predictions Inside!
Can the Colts solidify their lead in the AFC South? Get insights and predictions for Week 3 NFL matchups, including the Colts vs. Titans!

Is it time to believe in the Indianapolis Colts? As the NFL season heats up, the Colts have made a strong start with a record of 2-0. Under the leadership of quarterback Daniel Jones, the Colts currently hold a one-game lead over the Jacksonville Jaguars and a two-game advantage over both the Houston Texans and Tennessee Titans in the AFC South division.

One of the standout players for the Colts has been running back Jonathan Taylor, who has emerged as a top contender for the Offensive Player of the Year award. Taylor has amassed an impressive 313 combined yards in the first two weeks of the season, showcasing his ability to dominate on the field.

Upcoming Matchup: Colts vs. Titans

Looking ahead to Week 3, the Colts are set to face off against the struggling Tennessee Titans. A victory for the Colts, coupled with a Jacksonville win over Houston, could significantly narrow the AFC South race to just two teams as the regular season progresses. The Colts are currently favored by 3 points against the Titans, while the Jaguars hold a 1.5-point advantage over the Texans in their matchup.

If both favorites come out on top this Sunday, it could spell trouble for any futures bets that include the Texans as division champions, potentially shifting the landscape of the division for the remainder of the season.

AFC Storylines to Watch

In other notable AFC storylines, the Kansas City Chiefs are looking for their first win of the season against the New York Giants, with Kansas City favored by 6 points. Additionally, the Los Angeles Chargers aim to keep their momentum going with a home game against their AFC West rivals, the Denver Broncos.

Expert Predictions for Week 3

As we dive into Week 3 of the 2025 NFL season, SportsLine expert Eric Cohen has prepared detailed predictions for all 16 matchups. Cohen, who started the season with an impressive 12-4 record in Week 1 and followed up with an 11-5 performance in Week 2, has a strong history of profitability for bettors, boasting a 190-95 record (69%) in the previous season.

For those looking to make informed bets, Cohen favors the Bears to win and cover against the Cowboys with a line of -1.5 and a total of 50 points. Despite a shaky performance in recent games, Chicago showed promise in the first three quarters of their opening week. With both defenses struggling, Cohen anticipates this matchup to be one of the highest-scoring games of Week 3. Expect an offensive showdown from quarterbacks and key receivers alike, including CeeDee Lamb, George Pickens, D.J. Moore, and Rome Odunze.

Moreover, Cohen hints at a surprising underdog that he believes will cover in a game that seems to have trap line potential. Understanding these key insights can help you make profitable decisions for your Week 3 NFL picks.

For those eager to know which teams will emerge victorious in Week 3 and to uncover which game has trap line potential, be sure to join SportsLine and access Eric Cohen's expert score predictions today!

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