In recent years, several celebrities have openly discussed their experiences with Mounjaro and Ozempic, medications originally intended for Type 2 diabetes, which have gained popularity for their weight loss effects. Comedian Rosie showcased her remarkable transformation after starting Mounjaro in late 2022, posting on Instagram in May 2025, "I can't believe this is me now," along with hashtags like mounjaro, weightloss, and bodydismorphia.
After welcoming their first child, Riley, in 2021, singer Meghan Trainor and her husband, actor Daryl Sabara, embarked on the 75 Hard challenge as a couple. During an episode of their podcast, Workin’ On It, Meghan revealed how they turned to Mounjaro and Ozempic after noticing many friends and even doctors utilizing these medications for weight management. They each opted for the lowest dose available and combined it with exercise and a balanced diet, emphasizing the importance of journeying together through their health transformations.
Former Girls Next Door star Kendra Wilkinson shared her own experience with weight loss injectables, admitting on her Instagram Stories in April 2025 that she had tried one shot of an unnamed injectable but quickly abandoned it. Kendra expressed her concerns over potential health risks, stating, "Heard too many horror stories around me." The mother of two decided against continuing the medication after hearing about severe side effects experienced by others.
In March 2025, a well-known comedian and Golden Globes host passionately defended the use of Ozempic during an appearance on The Tonight Show Starring Jimmy Fallon. She urged individuals to feel more comfortable discussing their use of the medication, arguing that societal shame often comes from those who do not understand the challenges of weight loss. "The shame is only from thin people who want you to stay fat," she stated, encouraging transparency about weight loss methods.
Not all celebrities have had positive experiences with Ozempic. For instance, model Nader shared her struggles with nausea while using the drug, which interfered with her ability to participate in activities like Dancing With the Stars. Similarly, Dog the Bounty Hunter's daughter reported a significant weight loss of 58 pounds using Tirzepatide but revealed that her experience with Ozempic was quite negative, citing severe nausea that made eating difficult.
In a shocking account, Kate Moss' sister described her ordeal with Ozempic, which nearly led to a seizure due to dehydration after taking a dosage meant for heavier individuals. This harrowing experience illuminated the potential dangers associated with weight loss medications and served as a cautionary tale for others considering their use.
While some celebrities have touted their success with Ozempic, others like The Real Housewives of Atlanta alum have expressed frustration over their lack of results, citing instances where the medication failed to curb their appetite. This disparity in experiences raises questions about the effectiveness and safety of these weight loss solutions.
Despite the controversies and mixed reviews, the conversation around Ozempic and Mounjaro continues to grow. Celebrities like the 30 Rock alum have noted weight loss benefits from Ozempic, while others, including Heidi Montag, have spoken against the drug, emphasizing the importance of hard work and sustainable weight loss methods.
The ongoing discussion about Mounjaro and Ozempic highlights the complex relationship between weight loss and societal pressures. As more celebrities share their stories, it becomes increasingly important for individuals to consult healthcare professionals and consider the potential risks and benefits before embarking on their weight loss journeys. With the right approach, it’s possible to achieve health goals while prioritizing safety and well-being.
